CGPH FACULTY: Brenda Eskenazi
DATE OF PUBLICATION: September 2014
REGION: Europe
REFERENCE: Chevrier J, Warner M, Gunier RB, Brambilla P, Eskenazi B, Mocarelli P. Serum Dioxin Concentrations and Thyroid Hormone Levels in the Seveso Women’s Health Study. Am J Epidemiol. 2014 Sep 1;180(5):490-8. doi: 10.1093/aje/kwu160. Epub 2014 Aug 5.
SUMMARY/ABSTRACT: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant. Although experimental evidence suggests that TCDD alters thyroid hormone levels in rodents, human data are inconsistent. In 1976, a trichlorophenol plant exploded in Seveso, Italy. Women living in highly exposed areas were followed through the Seveso Women’s Health Study. TCDD exposure, particularly exposure before menarche, may have enduring impacts on women’s total thyroxine levels. Initial exposure appears to be more influential than remaining body burden.
ACCESS: Link to Pubmed