CGPH FACULTY: Nina Holland
DATE OF PUBLICATION: April 2015
REGION: Global
REFERENCE: Holland N, Lizarraga D, Huen K. Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children’s environmental health. Curr Opin Pediatr. 2015 Apr;27(2):240-7. doi: 10.1097/MOP.0000000000000192.
SUMMARY/ABSTRACT: Children are more susceptible to exposures in utero and during early childhood that may result in developmental problems and chronic diseases. Novel discoveries in the field of molecular epidemiology that can help explain susceptibility to exposures and disease will be demonstrated using the multifunctional enzyme paraoxonase 1 (PON1) as an example. This PON1 model demonstrates that integrating genetic and epigenetic factors, as well as other novel methodologies, can improve our understanding of important susceptibility factors linked to pediatric disease.
ACCESS: Link to Pubmed