CGPH FACULTY: Brenda Eskenazi
DATE OF PUBLICATION: February 2014
REGION: Europe
REFERENCE: Wesselink A, Warner M, Samuels S, Parigi A, Brambilla P, Mocarelli P, Eskenazi B. Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environ Int. 2014 Feb;63:143-8. doi: 10.1016/j.envint.2013.11.005. Epub 2013 Nov 30.
SUMMARY/ABSTRACT: Animal evidence suggests an association between exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and adverse pregnancy outcomes. Epidemiologic studies report inconsistent results, but are limited by narrow range of exposure, small sample size, and lack of a biologic measure of highest lifetime exposure. On July 10, 1976, a chemical explosion in Seveso, Italy resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women’s Health Study (SWHS), a retrospective cohort of TCDD exposure and reproductive health
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