Dioxin exposure associated with fecundability and infertility in mothers and daughters of Seveso, Italy

/ / Faculty Research in Europe, Research

UC BERKELEY AUTHORS: Brenda Eskenazi, Jennifer Ames, Stephen Rauch, Nina Holland, Marcella Warner


REGION: Europe

DOI: https://doi.org/10.1093/humrep/deaa324

SUMMARY/ABSTRACT: In animal studies, maternal exposure to TCDD is associated with decreased fertility in offspring. Effects of TCDD are mediated by activation of the aryl hydrocarbon receptor (AHR) pathway. Consistent with previous findings in animal studies, our study found that TCDD exposure may be associated with decreased fertility in Seveso mothers and potentially in their daughters exposed in utero.

ACCESS: https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deaa324/6050546