CGPH FACULTY: Lee Riley
DATE OF PUBLICATION: May 2015
REGION: Latin America
REFERENCE: Ribeiro FK, Pan W, Bertolde A, Vinhas SA, Peres RL, Riley L, Palaci M, Maciel EL. Genotypic and Spatial Analysis of Mycobacterium tuberculosis Transmission in a High-Incidence Urban Setting. Clin Infect Dis. 2015 May 5. pii: civ365.
SUMMARY/ABSTRACT: “Genotyping Mycobacterium tuberculosis isolates allows study of dynamics of tuberculosis transmission, while geoprocessing allows spatial analysis of clinical and epidemiological data. Here, genotyping data and spatial analysis were combined to characterize tuberculosis transmission in Vitória, Brazil, to identify distinct neighborhoods and risk factors associated with recent tuberculosis transmission. Spatial and genotypic clustering of M. tuberculosis isolates revealed ongoing active transmission of tuberculosis caused by a small subset of strains in specific neighborhoods of the city. Such information provides an opportunity to target tuberculosis transmission control, such as through rigorous and more focused contact investigation programs.
ACCESS: Link to Pubmed