CGPH FACULTY: Eva Harris
DATE OF PUBLICATION: January 2010
REGION: Latin America
REFERENCE: Balmaseda A, Standish K, Mercado JC, Matute JC, Tellez Y, Saborío S, Hammond SN, Nuñez A, Avilés W, Henn MR, Holmes EC, Gordon A, Coloma J, Kuan G, Harris E. Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua. J Infect Dis. 2010 Jan 1;201(1):5-14. doi: 10.1086/648592.
SUMMARY/ABSTRACT: Dengue is the most prevalent mosquito-borne viral disease in humans and a major urban public health problem worldwide. A prospective cohort study of approximately 3800 children initially aged 2-9 years was established in Managua, Nicaragua, in 2004 to study the natural history of dengue transmission in an urban pediatric population. Blood samples from healthy subjects were collected annually prior to the dengue season, and identification of dengue cases occurred via enhanced passive surveillance at the study health center. This large-scale cohort study of dengue in the Americas demonstrates year-to-year variation of dengue within a pediatric population, revealing expected patterns in transmission while highlighting the impact of interventions, climate, and viral evolution.
ACCESS: Link to Pubmed