Serum Dioxin Concentrations and Bone Density and Structure in the Seveso Women’s Health Study

/ / Faculty Research in Europe, Research

CGPH FACULTY: Brenda Eskenazi

DATE OF PUBLICATION: January 2014

REGION: Europe

REFERENCE: Eskenazi B, Warner M, Sirtori M, Fuerst T, Rauch SA, Brambilla P, Mocarelli P, Rubinacci A. Serum Dioxin Concentrations and Bone Density and Structure in the Seveso Women’s Health Study. Environ Health Perspect. 2014 Jan;122(1):51-7. doi: 10.1289/ehp.1306788. Epub 2013 Nov 12.

SUMMARY/ABSTRACT: Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is a known endocrine disruptor. Objectives: On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women’s Health Study, a retrospective cohort study of the health of the women. In 2008, we followed up the cohort. Here, we evaluated the association between TCDD exposure and bone structure and geometry in adulthood, and considered whether timing of TCDD exposure before achievement of peak bone mass (assumed to occur 2 years after onset of menarche) modified the association.

ACCESS: Link to Pubmed