CGPH FACULTY: Eva Harris
DATE OF PUBLICATION: November 2011
REGION: Latin America
REFERENCE: Gutierrez G, Standish K, Narvaez F, Perez MA, Saborio S, Elizondo D, Ortega O, Nuñez A, Kuan G, Balmaseda A, Harris E. Unusual dengue virus 3 epidemic in Nicaragua, 2009. PLoS Negl Trop Dis. 2011 Nov;5(11):e1394. doi: 10.1371/journal.pntd.0001394. Epub 2011 Nov 8.
SUMMARY/ABSTRACT: The four dengue virus serotypes (DENV1-4) cause the most prevalent mosquito-borne viral disease affecting humans worldwide. In 2009, Nicaragua experienced the largest dengue epidemic in over a decade, marked by unusual clinical presentation, as observed in two prospective studies of pediatric dengue in Managua. nfluenza A-H1N1 2009 in Managua was shifted such that it overlapped with the dengue epidemic. We hypothesize that prior influenza A H1N1 2009 infection may have modulated subsequent DENV infection, and initial results of an ongoing study suggest increased risk of shock among children with anti-H1N1-2009 antibodies. This study demonstrates that parameters other than serotype, viral genomic sequence, immune status, and sequence of serotypes can play a role in modulating dengue disease outcome.
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